We are studying germline de novo mutations arising at meiotic DNA double-strand breaks (DSBs). Our goal is to elucidate the mutagenic potential of the meiotic genome, and the molecular mechanisms driving de novo mutations and understand their impact on genome stability and evolution. We investigate mutational outcomes, in particular, structural and copy number variants, in mouse and human germlines, using genetic and molecular assays in conjunction with deep sequencing and computational analyses. Our laboratory is located in the Department of Human Genetics at the University of Michigan.